AIC Therapy in Cancer

In cancer cells, calcium signaling is a critical regulator of metabolic processes that support cell survival. It specifically enhances the activity of TCA cycle enzymes, such as isocitrate dehydrogenase and oxoglutarate dehydrogenase, which are vital for producing the metabolic intermediates required for rapid proliferation. Beyond its metabolic support, calcium is essential for maintaining mitochondrial membrane potential and preventing apoptosis. Additionally, calcium is crucial in activating calmodulin-dependent kinases, directly influencing key signaling pathways governing cell cycle progression and resistance to apoptosis.