calcium dysfunction & solutions

ACRI studies calcium dysfunction & develops solutions

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**ACRI** Brings novel Technology

Despite the many advancements in medical technology, incidents of debilitating conditions such as osteoporosis, arthritis, cancer, and Alzheimer’s disease are still rising. Utilizing its proprietary antiorbital formulation technology, **Advanced Calcium Research Institute (ACRI)** supports physicians in building effective remedies for these difficult diseases. By utilizing a ubiquitous cellular signaling agent, namely ionic calcium, ACRI found many ways to trigger natural healing responses. Rather than just treating symptoms, our approach is helping our body to overcome sickness by strengthening our body’s natural self-healing capabilities by focusing on reversing the root causes of diseases.

Our **Commitments**

Our signature **Antiorbital Ionic Calcium (AIC) technology** delivers ionic calcium in the supplement form. It effectively pulls our system back into the proper balance by restoring and correcting our body’s most basic cell communication system based on calcium oscillation. When our body communicates correctly, healing takes place. Because calcium signaling dysfunction affects all of us with aging and makes us vulnerable to hosts of degenerative diseases, ACRI is dedicated to finding applications of AIC technology for many different disease conditions with ongoing clinical research.

**Ionic Calcium Therapy** has supported the health of **over**
**10,000 people**

Many physicians and their patients have already voluntarily participated in our clinical research projects and provided feedback in fine-tuning the therapy.
Bringing a safe and easy supplement-based approach to optimal health that truly delivers is the grand goal of ACRI.

Dr. Server Bozdogan (MD, Ph.D. Geneticist) of Advanced Calcium Research Institute focuses on finding more applications for ionic calcium therapy.

ACRI & CBHI Research Team

Sever Bozdogan (Genetics, MD, Ph.D.) - Director of ACRI
Paul Lee (Chemistry, Ph.D.) - Director of CBH
Martin Chun (Material, Ph.D.)
O.S. Lee (Foods Science, Ph.D.)

ACRI Director’s Introduction

Thank you for your interest in the Advanced Calcium Research Institute (ACRI).

Our primary objective is to shed light on the role of calcium in various diseases beyond its established association with osteoporosis. In addition, recent discoveries have provided new insights into the multifaceted involvement of calcium in numerous other medical conditions, such as cancers, and neurodegenerative diseases.

With our unique positioning, ACRI can potentially impact alternative medications significantly. Leveraging our existing strengths and harnessing the potential of our innovative AIC formulation biotechnology, we collaborate with local, national, and global affiliations to bridge the gap between discoveries and develop superior treatment options.

We trust that you will find the ACRI website both captivating and enlightening. We invite you to explore our website for deeper insights into our work. Please feel free to delve into the ACRI website further into our work.

Dr. Server Bozdogan, Ph.D., Molecular Geneticist

Director of ACRI

Edward Lee (Materials Eng. Ph.D.)
James Lee (Toxicology, Ph.D.)
W.S. Kim (Material, Ph.D.)
Chris Choe (Energy, Ph.D.)

**Continued Research**
Expands the Horizon

Joining hands with many healthcare practitioners and clinics around the world, ACRI expands the application of AIC therapy as both adjunct and adjuvant therapy to both conventional and naturopathic treatments in treating many difficult conditions. Invited to speak in many health and medical conferences around the world, our affiliated practitioners engage and partner with experts in the science field. The ongoing collaborative research continues to support our participating practitioners and clinics, bringing hopes of restored health to countless patients.

**Multiple myeloma**
Research with **UAMS**

The experts of multiple myeloma cancer research in the UAMS Rockefeller Cancer Institute are partnering with us in studying and finding the promising effects of AIC in future treatments for this debilitating disease. The research is currently ongoing as of 2020.

Multiple myeloma (MM) is the second most common hematological malignancy. It mostly occurs at older ages and remains an incurable disease. MM is a B cell cancer mainly characterized by the proliferation of malignant plasma cells in the bone marrow, the presence of monoclonal serum immunoglobulin, and the occurrence of osteolytic lesions. Bone remodeling effects of AIC by increasing the bone turnover rate through stimulation of osteoclast and osteoblast activity place AIC as a good candidate for novel myeloma therapy.

our Research Partners

Partnering organizations

UPCOMING CONFERENCES for 2023

**Antiorbital iconic Calcium** (AIC - CaCO3)

**The result of 10 years of intense research and development**
AIC (Antiorbital Ionic Calcium) is the world’s true first calcium-ion delivery system which safely and effectively elevates the threshold level of calcium-ion concentration in our blood (0.1mg/dL) to initiate a cascade of hormonal responses that helps awaken our body’s natural healing mechanisms!

**WHAT IS SCIENCE BEHIND AIC?**

AIC is a medical-grade product derived from SAC. AIC pushes the threshold of purity level to 99.9%. Comparing it with SAC, AIC has a significantly higher absorption rate and achieves the highest physiological effects.
When AIC is absorbed into the body, it is absorbed by the electric potential difference in the body (passive transport). As the force E=-13.6/n2 (eV) increases, it is separated from the CO3 of AIC CaCO3. At this time, the 4s orbital of the calcium atom disappears and the calcium atom becomes a calcium ion. This is called Anti-orbital Ionic calcium.

**CALCIUM SIGNALING AND FUNCTIONS**

Calcium atom has a 4s orbital in the last orbit and has 2 electrons in it. This electron has a force of mγ2/r, and when mγ2/r becomes larger, the 2 electrons fall apart, and the calcium atom is in an ionic form. It becomes plasma, which becomes an indispensable element in human cell metabolism. The continuous research and development of CBHI in creating calcium ions made us possible to manipulate AIC CaCO3 with high electric energy; this process allows AIC CaCO3 to efficiently ionize by the cell voltage (electronic difference) of the human body for a certain period. This element, we call Anti-orbital Iconic Calcium (AIC), is specifically made for medical use.

Testimonials

Kidney functions rapidly improving!

Years of dysfunctional kidneys sucked the life out of me and even turned my face into a deathly dark color. I tried everything from eastern to western medicines, but nothing seemed to help. Then at the plea of a close friend, I started taking MaraGen. In about a month, I have noticed that my face turned back to normal and my body felt much better.

I thought it was the effects of all the medication I had been taking, and immediately stopped taking the MaraGen. (I thought it was a bit pricey.) I felt good for a few days, but then my condition deteriorated slowly, and in about two weeks my face started to turn dark again. I got back on MaraGen again and discovered how amazing and powerful the product was. Experiencing rapid restoration of my kidney functions and seeing my normal face again in the mirror is simply unbelievable! I thank my friend and Pronuvia for these wonderful products.

- C. Park - Male, 65, Singapore (Stage 4 Chronic Kidney Disease with gout and diabetes with insulin, overweight)

No bone graft needed for implant. DentiGen did the job!

My dentist extracted my molar tooth with cavity 6 months ago. He recommended that I do an implant after bone graft. I then remembered hearing about DentiGen and told him that I would come back after increasing my jaw bone density. The dentist said that there is simply no way to increase jaw bone density and that he would eat his hat if my bone density increased. For a few months I took DentiGen faithfully and visited the dentist. He could not believe what he saw in xrays! He did not end up eating his hat but confirmed that now implant is doable due to increased jaw bone density. Wow!

(Soonok Chung – Age 47, Female)

10 years of arthritis pain kept me from walking normally. CartiGen took it away in two weeks!

I was hit with rheumatoid arthritis about 10 years ago. To escape stiffness and pain, I tried everything, including numerous gold injections that cost over $1000 per shot! My fingers were bent and knee pain was unbearable. My toes also hurt so much that I could not walk properly. I could not let my big toe touch the ground. Numerous doctor visits gave me different diagnosis such as virus, genetics, etc. which did not help me at all. On February 8th (2017), my friend introduced my to CartiGen. After taking it for two weeks, the pain subsided dramatically, and now I can walk normally with my toe touching the ground! Two weeks of CartiGen took care of 10-year-old problem! I met a savior! Thank you, Pronuvia, and my friend who got me into AIC therapy.

(Jung Cho – Age 66, Female, Surrey, Canada)

MaraGen delivered me from two years of weekly transfusion. My marrow now generates my own blood!

I have been getting blood transfusion every week for the past two years because my bone marrow can no longer generate new blood cells. The quality of my life was deteriorating due to constant suffering and weariness. Then my Iranian friend recommend me to take MaraGen. I couldn’t help being skeptical at first since I have been in living in despair for all this time with no real help offered from medical world for my condition. However, learning of his own miraculous recovery from critical heart condition through MaraGen, I had to give it a try. I started to take MaraGen three times a day for a month and then noticed diminishing symptoms of anemia. Surprisingly, the next blood test revealed that my marrow began to make new blood of my own!! Ecstatic and regaining hope, I can now feel that I am returning to normal health. I recently stopped receiving transfusion, escaping the misery of weekly transfusion! I am so grateful for Pronuvia and also for my friend who introduced me to this miracle supplement. I am convinced that I am on the road to full recovery. (July, 2017)

(Namkyu Park – Age 48, Male, BC, Canada)

A tumor size of golf ball behind my eye is gone!

As a US Air Force pilot, I was devastated when I was diagnosed with a brain tumor the size of a golf ball behind my eye. I was then introduced to MaraGen. I took it for three months before I got another brain scan at the Washington Bethesda Medical center. The doctor asked me incredulously, “How come I do not see that golf ball sized tumor?” MaraGen is a miracle!

(Merry – Age 30, Female)

Not only my thyroid cancer receded, my bone density improved significantly!

I was scheduled to take surgery for thyroid cancer in the hospital. After taking MaraGen, I began to feel much better, and incredibly, the cancer disappeared. My doctor was shaking his head and asked me how I managed this miraculous recovery. What’s more? My bone density improved from T-score -4.9 to -3.4. I heard such increase is not possible. Only with MaraGen! Thanks you!

(E. H. Son – Age 52, Female)

more testimony

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**Natural Healing** Process

**AIC provides enough calcium ion directly into our system to trigger cascade of hormonal responses to bring in natural healing process**
Slight elevation of calcium ion concentration in our body do wonders following the natural pathways inherent in our system. Over a hundred calcium-related diseases can find help.

**How AiC** Ionic Calcium Therapy **started**

In 2009, Dr. Paul Lee of CBHI invented Antiorbital Ionic Calcium (AIC) in an effort to make better biological calcium. When his friend remarkably improved from the late stage of prostate cancer with colon metastasis, intensive research on physiological application started, discovering its efficacy on many degenerative diseases such as osteoporosis, Parkinson’s, autoimmune diseases, etc.
Ever since, many interested physicians have started to use AIC for various diseased conditions and have reaped great benefits. AIC Ionic Calcium Therapy soon became one of the favorite and praised therapies employed by over a thousand physicians worldwide already. This innovative new therapy rebuilds and restores our body from the cellular level and complements and enhances any existing treatments by magnifying their effectiveness as well.

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conditions tried WITH BENEFITS

Bone & teeth health
Heart and muscle contraction
Blood clotting
Cell/DNA replication
Cellular communication
Hormone regulation
Enzyme activation
Mineralizer
Neurotransmitter
Normalizing Immune response
Healthy Cell Replication

Cell Membrane Integrity
Osteoporosis
Arthritis
Arrhythmia
Crohn’s disease
Calcium-related infertility
Bone Necrosis
Heart palpitation
Calcific tendonitis
Lyme Disease
Epilepsy

Diabetes
Alzheimer’s
Viral Infection (HIV)
ALS
Cancer (Carcinoma, Sarcoma, Lymphoma)
Parkinson’s disease
Gout
Autoimmune Disease (Lupus)
Inflammation
Mitochondrial Disease

Remarkable Recovery Under AIC

Diagnosed with Multiple Myeloma (2012)

2012 Diagnosed with Multiple Myeloma

2013 Started AIC Therapy

2015 Fully Recovered in 14 months.

Ms. Holt’s hematological data, such as platelet, WBC, and neutrophil, normalized and later declared cancer-free.

Ms. Holt’s kidney, damaged by chemo, has recovered. Also, her GFR bounced from 12 to 62, to a normal range for her age.

Ms. Holt’s BMD score also significantly improved after treatment with AIC, and she fully recovered from osteoporosis. (T score increased from -3.6 to -0.9, back to the normal bone density)

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Diagnosed with cervical cancer (2012)

•Year 2012: Diagnosed with cervical cancer. Underwent radical trachelectomy

•April 2016: Recurrence of cancer.

•Nov 2016: Chemotherapy

•Jan 2017: Tumor grows back

•Feb-May 2017: Chemo and Radiation Therapy

•May 2017: Ongoing presence of cancer discovered

•May 2017: Starts AIC Therapy (AIC 3-4x /day)

•Sept 2017: Declared cancer free after TRU CUT Biopsy

•Sept 2017: Stops AIC Therapy prematurely

•Feb 2018: Recurrence of Cancer

•May-Sept 2019: Cryoablation & Ethanol Ablation in Guangzhou, China. Tumor size decreased, but cancer was still present.

•Nov 2019: Started AIC Therapy again (AIC 4x/day)

•Sept 2020: Declared cancer-free under AIC (Again) !!

•Aug 2021: After PET Scan still clinically cancer free

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Diagnosed with Adenoid Cancer (2016)

“I am 51 years old and have worked as a motel manager for a long time. The stress from my work and constant heavy drinking after work took a toll on my body. Then one day, I noticed a growth inside my left cheek and had to rush to see my doctor. The test revealed that the mass was cancerous. The tumor had a diameter of 3.5 cm and was growing where nerve and blood vessels were intricately intertwined. My oncologist recommended me for surgery because radiation therapy was not deemed helpful then.

Last September 2016, I heard about AIC through my brother but decided to follow the oncologist's recommendation and surgically remove the big tumor. Many smaller tumors where surgical removal was not possible were left alone. Right after the surgery, I started to take AIC. I immediately experienced my body temperature rising and felt much stronger even after exhaustive chores from my work. I began to have both wonder and hope.

About twenty days after the surgery, the hospital called me and tried to convince me to receive 33 scheduled radiation therapy treatments. When I inquired and learned about the terrible side effects of the treatment, I could not muster the courage to go ahead with it. I decided not to take radiation therapy and rely on AIC since I was already experiencing various positive effects. Honestly, the side effects of the recommended radiotherapy, namely, dry mouth, hot flush, losing taste buds, and possible brain hemorrhage, sounded scarier than cancer itself.

Now, I am so glad I bypassed the radiation therapy and stayed with AIC. AIC removed all the traces of remaining cancer, even in the most difficult places.” (March 2017)

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