THE Therapy in a Nutshell
Studies on degenerative conditions indicate that more than 150 chronic ailments are linked to disturbances in cellular calcium equilibrium. Hormonal changes associated with aging and chronic bone loss can inundate vital cellular calcium reservoirs, resulting in disrupted calcium signaling, which can trigger mitochondrial dysfunction and oxidative stress. To counteract the damaging effects of calcium dysfunction, Antiorbital Ionic Calcium (AIC) therapy employs a formula that releases ionic calcium, which initiates a healing cascade of hormones. AIC stimulates physiological responses that are sensitive to ionic calcium and combats illnesses at their core.
What is antiorbital calcium?
AIC is the world's first safe calcium-ion delivering molecule administered orally. Ionic calcium triggers body-wide calcium homeostasis no other calcium supplementation can achieve.
The discovery that made difference
Anti-orbital Ionic Calcium Carbonate (AIC-CaCO3)
AIC IONIC CALCIUM CARBONATE
Has electrical charge from weak anti-bonding
REGULAR CALCIUM CARBONATE
Strong bonding and no net electrical charge
How is AIC Calcium Carbonate Different?
Introducing AIC - the first calcium-ion-delivering calcium carbonate in the world. It safely and effectively increases the concentration of calcium-ion in our blood. Through the utilization of a weak antiorbital chemical bonding to calcium carbonate molecules, and stabilizing it inside structured water molecules, AIC calcium carbonate displays unique physical and chemical properties. It is 200 times more soluble and 3 times more active chemically.
Molecules exhibit electrical polarity due to anti-orbital bonding, which attracts water molecules through hydrogen bonding. Achieving stability of antibonding at room temperature was a significant technological breakthrough that took ten years of research and development.
How Does AIC Calcium Carbonate Work?
The weak chemical bonding of AIC allows for easy detachment of calcium ions, which are then passively absorbed into the body through the stomach lining via diffusion and osmotic pressure. Unlike other calcium products, this absorption process does not require digestion, vitamin D, or peptides. Due to the body's sensitivity to changes in serum plasma ionic calcium levels, even a minimal increase in AIC's serum ionic calcium concentration can trigger hormonal responses, such as the release of TSH and calcitonin, to initiate bone-building osteoblasts. AIC therapy utilizes ionic calcium as a signaling agent to prompt the body's self-healing responses to reverse calcification at the cellular and systemic levels, resulting in a series of healing processes that rebuild overall health. The unique healing pathway of AIC sets it apart from other treatments.
AIC IONIC CALCIUM CARBONATE with ANTIORBITAL BONDING
REGULAR CALCIUM CARBONATE with IONIC BONDING
During regular calcium digestion, both positively charged calcium ions and negatively charged anions are produced, resulting in an electrically neutral outcome. However, in the case of AIC, it dissolves on the stomach wall into calcium ions and neutral molecules like oxygen and carbon dioxide without any negative charges, resulting in a net positive charge.
Whether from food or supplements, when calcium is digested in our stomach by strong hydrochloric acid, calcium ions are released as the ionic bond of the molecules are broken and both cations and anions are released. However, the net charge of the reaction is zero. All calcium ions descend to small intestine where it binds with vitamin D and peptides and absorbed as protein-bound calcium.
What is Antiorbital Bonding?
Anti-bonding orbitals are essentially the “opposite” of bonding orbitals.
They are formed when atomic orbitals combine, leading to predominantly destructive interference.
The key feature of anti-bonding orbitals is that the molecular orbitals have higher energy than the corresponding atomic orbitals. Thus, the molecule has a higher energy than the separated atoms (atoms separated by a large distance), and the atoms would prefer to be in the lower atomic state.
Anytime two atomic orbitals combine to give a lower-energy bonding orbital, an analogous higher-energy anti-bonding orbital is also formed. Take a look at a figure depicting this simple bond/anti-bond molecular orbital diagram that we had for hydrogen. The diagram also shows that electrons (in this case) completely fill the bonding orbital and leave the anti-bonding orbital empty.
AIC calcium’s antiorbital bonding keeps the calcium atoms in the molecule very loose and unstable. Our innovative technology locks calcium atoms in place until it is released into our body. A highly advanced process formulates it to maintain positive charges (2+) by altering the bonding structure into antiorbital-bonding. The positive charges of the molecule attract water molecules to cluster around it, making it incredibly water-soluble and allowing direct and passive absorption into the body.
AIC absorption vs. Other calcium
AIC calcium absorption is passive without the energy required
Normal Calcium Absorption requires digestion and energy
Calcium from AIC is quickly absorbed due to its positively charged antiorbital-bonding, making it readily available for the body to use. Unlike other forms of calcium that require digestion with peptides and vitamin D through active transport delivery, which can make the absorbed calcium less effective, AIC bypasses this complicated process for immediate bio-availability.
Unique Physical Properties of AIC Calcium
Because of the electrical charge of AIC ionic calcium carbonate molecules that interacts with the hydrogen bonding of water molecules, an open bottle of AIC evaporates calcium together with water molecules and crystalizes with CO2 in the air.
AIC is 200x more soluble in water compared to calcium carbonate and 3x more reactive in chemical reactions.
Active Transport of Regular Calcium
Regular calcium intake from diet or supplements need strong stomach acid with peptides and vitamin D3 to digest and be absorbed in small intestines as protein-bound calcium, which is not readily utilized with aging because of a sedentary lifestyle, hormonal changes, and poor diet. Various side effects of inactive calcium include kidney stones, blood vessel calcification, stroke, heart attack, etc. Most, if not all, calcium supplements fall in this category and may aggrevate body-wide calcification which is known to be one of many major cause of degenerative diseases.
Passive Transport of AIC Calcium
Unlike regular calcium intake, no Vitamin D3 and peptides are needed for absorption. AIC diffuses passively through digestive tract cell linings (mucosa) as ions, not requiring physiological energy from our body and readily available for immediate use.
Ionic calcium is immediately utilized to bring calcium homeostasis :
Corrects calcium signaling
Reduces cellular oxidative stress
Restores mitochondrial function
Triggers decalcification
AIC is Absorbed through Diffusion & Osmotic Pressure
About 5 to 8 mg of AIC solution is mixed with 500ml of water for optimum absorption as ionic calcium. AIC is taken on an empty stomach and is completely absorbed within 30 minutes through diffusion and osmotic pressure. Although it is in a small intake amount, a slight elevation of serum ionic calcium level is enough to trigger TSH (thyroid stimulating hormone) to initiate strong bone-building osteoblasts. AIC’s cascading effects on the physiological functions of our body also activate inactive protein-bound calcium in our blood to boost further and maintain good bone health.
Channel & Intracellular Calcium ion Levels
Modes of regulated calcium entry across the membrane
AIC is the first calcium-ion-delivery-system to help build and support strong bones while promoting normal bone mass. AIC also plays an important role in other functions such as nerve transmission and muscular function. Unlike other electrically neutral calcium supplements that require Active Transport, AIC calcium’s Passive Transport brings full absorption of calcium without the need for Vitamin D, peptide, or other agents.
Inside our cells, AIC ionic calcium quickly breaks down to yield calcium ions, which are absorbed into capillaries and triggers our body’s natural bone formation process.
STRONGER BONES LEAD TO A HEALTHIER LIFE
According to a follow-up study conducted in Denmark with 35,000 participants, individuals in their 50s with strong bones had a life expectancy that was 11.6 years longer than those with weaker bones.
Recent research also shows that senior women who have low bone density are more than twice likely to develop Alzheimer's disease.
Physiological Effects of ionic calcium therapy
After intake, AIC’s effect lasts about four hours in our body, initially raising the serum ionic calcium concentration to a higher yet safe level to trigger various physiological functions before bringing down the serum ionic calcium concentration down to the average physiological level.
While ionic calcium level is elevated, bone-building osteoblast with osteoclastic activity is triggered to raise the bone turnover rate, repairing and rebuilding bones. This process also activates idle protein-bound calcium, releasing both ionic calcium and protein, further fueling bone-building and clearing body-wide calcification. Ionic calcium also aids cellular metabolism, releasing more ATP (adenosine triphosphate) and raising body temperature. As kidneys try to excrete excess ionic calcium through urination, an urge to urinate within an hour of taking AIC is experienced, which is both healthy and normal, indicating that AIC is working.
Bone Loss Leads to 150+ Degenerative Diseases
Bone health is directly related to our overall health. Emptier bone characterized by osteoporosis or osteopenia indicates a higher risk of fracture and a greater chance of developing degenerative diseases. Why? Because emptying bones cause calcification in both cellular and systemic levels, causing cellular communications mayhem by disrupting calcium signaling.
Bone density peaks around age 30 and starts to decrease around age 35. Women with menopause have a sharper decline than men, posing a higher risk of osteoporosis. Stress, a sedentary lifestyle, and toxins accelerate the drop.
Cellular Calcification can lead to Mitochondrial Dysfunction, Cellular Inflammation, Oxidative Stress, and Calcium Signaling Breakdown.
CATEGORY A
Most people fall under this category. With aging, parathyroid hormone (PTH) becomes more active and takes out more calcium ion from bones than needed and causes weaker bones and bodywide calcification.
CATEGORY B
More health-conscious people. Slow aging with a healthy diet and bone-challenging exercises that keeps bones strong, leading to less calcification. The onset of calcium-related degenerative diseases is delayed.
CATEGORY C
With AIC Therapy, thyroid hormone (TH) led bone-building restores calcium homeostasis and leads to body-wide decalcification, which helps to reverse calcium-related degenerative diseases.
STRENGTHENING THE BONE IS A KEY TO HEALTHY LIFE
“While a calcium deficiency is always present in the bones of individuals with chronic disease and is especially severe in those with osteoporosis, it is precisely the chronic loss of calcium from its large bony reservoir that continually feeds the excess presence of calcium elsewhere in the body.” Dr. Thomas Levy, Cardiologist
Age-related boneless causes cellular calcification, which renders two crucial cellular calcium buffers: ER and mitochondria. When the buffering capacity of these organelles is compromised, it distorts calcium signals that cause mitochondrial dysfunction, transcriptional errors, elevated oxidative stress, and cell process degradation.
HEALTHY BONE PREVENTS CALCIUM DYSFUNCTION
“A wide range of Ca2+ signaling systems deliver the spatial and temporal Ca2+ signals necessary to control the specific functions of different cell types. However, these homoeostatic systems are highly plastic and can undergo a process of phenotypic remodeling, resulting in the Ca2+ signals being set either too high or too low. Such subtle dysregulation of Ca2+ signals has been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder, and Alzheimer's disease.”*
*Calcium signaling remodelling and disease Michael J. Berridge, Biochemical Society TrantionsMar 21, 2012
CELLULAR DE-CALCIFICATION AS HEALING PATHWAYS
“Given its ubiquitous role, it is predictable that a deregulation along any point in the calcium signaling pathway may be capable of disrupting neurological function, which has already been demonstrated by a number of ‘calciumopathies’ – a diverse group of diseases caused by a disruption of calcium homeostasis.”
(Geert Bultynck and Jan Parys, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA)
CALCIUM THERAPY IS NOT CALCIUM SUPPLEMENTATION
It is important to consume around 1000mg of calcium daily, ideally through a healthy diet. However, as we age, our digestive power weakens, making it difficult to absorb the necessary calcium. To address this, doctors often recommend calcium supplements that are easier to absorb thanks to added vitamins D3 and K2. Nevertheless, some orthomolecular doctors caution against calcium supplementation due to the potential risks of increased calcification and associated health issues, such as heart attacks.
It is worth noting that AIC therapy is not the same as calcium supplementation. While it is still important to consume an adequate amount of calcium, a small amount of 'ionic' calcium can trigger unique health benefits that protein-bound calcium cannot provide. In fact, AIC can even help the body to more effectively utilize inactive protein calcium by activating it and directing it to where it is needed.
Targeting Secondary Cause of Disease Stops Disease Progression
We are familiar with the primary causes or root causes of disease. It could be toxins like heavy metals, chemicals, or mycotoxins. It could be pathogens like bacteria and viruses. Or it could be genetic disposition or unhealthy lifestyle that triggers inflammation and oxidative stress. Many doctors focus on eliminating these primary causes as an important part of comprehensive treatment.
However, the research world has identified a secondary cause of diseases that follows the root causes and plays a huge role in accelerating disease progression and amplifying symptoms: ionic calcium signaling dysfunction, also known as calciumopathy. When cellular calcium signaling is compromised, cells act abnormally and also cause mitochondrial dysfunction. Therefore, it has been suggested that protecting cellular homeostasis could prevent the progression of disease. AIC therapy plays an important role in normalizing dysfunctional calcium signaling and restoring correct cell behaviors.
PROMISING AIC THERAPY RESULTS
Radical bone turnover in animal trial
Animal study done on bone building. The same human dosing calibrated to the animal weight was administered daily for 9 weeks. AIC proved to be 100% more effectively compared to calcium carbonate in bone strength test and bone composition analysis. No match!
Calcium ions in the blood are so vital that the body cannot permit it to fluctuate. Therefore, even a slight increase in ionized calcium concentration in the blood triggers the bone-building process to take excess calcium into bones. Utilizing this process is the most effective and safe way to support strong bones since it follows the body’s natural bone-building mechanism. This amazing effect of AIC was observed in this animal clinical trial through the bone break test, where AIC ‘treated’ bone displayed almost 100% more bone-building power than regular calcium carbonate.
The effects of Antiorbital Ionic Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats are studied. The study revealed that the induced osteoporosis was completely reversed with AIC therapy. Osteocalcin, estradiol, eosinophil, CTx, and BMD levels were elevated with AIC, indicating that optimal bone health is restored.
Values are mean ± SD for five rats. Means with different superscript letters are significantly different at p<0.05 by Duncan’s multiple range tests.
Control: sham operation
OVX: no treatment after Ovariectomy
OVX+AIC: AIC Therapy after Ovariectomy
NOTABLE BONE DENSITY INCREASE IN HUMAN TRIAL
CBHI (Canada) utilized FDA approved ultrasound bone densitometer by BeamMed in measuring and comparing the BMD data of more than a thousand patients. Over 90% of the patients experienced increased bone density.
The benefits of AIC therapy extend beyond simply strengthening bones. While the majority of the body's calcium is stored in bones, the small amount present in the bloodstream plays a disproportionately important role in maintaining good health. Roughly 50% of this circulating serum calcium is "ionized," meaning it carries electrical charges. These calcium ions (Ca2+) are the only form that the body recognizes and are responsible for various functions, such as muscle and nerve cell activation, blood clotting, preserving bone mass, and maintaining proper cellular functions through calcium signaling.
Unfortunately, as we age, the delicate balance of ionic calcium homeostasis is disrupted as our bones deteriorate and calcify trillions of cells. AIC therapy can help restore this fragile calcium balance, giving the body a fighting chance against over 150 degenerative diseases that are believed to be caused by calcium displacement. Therefore, rebuilding bone health is not just to reduce fracture risks but also to restore cellular health to prevent hosts of degenerative diseases,
SIGNIFICANT BONE DENSITY RISE
A volunteer study at CBHI shows that many women who struggle with postmenopausal bone loss experienced notable BMD (Bone Mineral Density) increase after undergoing AIC therapy.
Compare BMD before (Blue bar) with BMD after the therapy (Green bar). X-axis represents the osteopenia borderline, and Y-axis represents the T-score.
UNderstanding Calcium Homeostasis
Bone is the major storage site for calcium in the body, and movement of calcium into and out of bone helps determine blood calcium\ levels, which is critical for normal muscle and nervous system function. Calcium (Ca2+) moves into bone as osteoblasts build new bone and out of bone as osteoclasts break down bone. When osteoblast and osteoclast activity is balanced, the movements of calcium into and out of a bone are equal.
When blood calcium levels are too low, osteoclast activity increases, osteoclasts release calcium from bone into the blood, and blood calcium levels increase. Conversely, if blood calcium levels are too high, osteoclast activity decreases, osteoblasts remove calcium from the blood to produce new bone, and blood calcium levels decrease.
Calcium homeostasis is maintained by three hormones: parathyroid hormone (PTH) from the parathyroid glands, vitamin D from the skin or diet, and calcitonin from the thyroid gland. PTH and vitamin D are secreted when blood ionic calcium levels are too low, and calcitonin is secreted when blood ionic calcium levels are too high. When serum ionic calcium level is slightly increased by the therapy, the thyroid releases calcitonin, which works to decrease blood calcium levels by inhibiting osteoclast activity. Even in the absence of osteoclast activity, osteoblast activity continues, removing calcium from the blood and depositing it into the bone.
In summary, PTH, vitamin D, and calcitonin work together to keep blood calcium levels within the homeostatic range, and this process can be triggered by AIC therapy.
Calcium Balance
It’s all about communication
Ionic calcium level is possibly the most precisely regulated substance out of all the minerals, vitamins, enzymes, and hormones. Many organs including thyroid, parathyroids, kidneys, intestines, and bones are all working together constantly in keeping the calcium level where it needs to be. Even in cellular level, many types calcium channels, mitochondria, and endoplasmic reticulum works constantly to keep intracellular calcium level at where it needs to be. Why? Because of ionic calcium’s role in communication. Precise calcium signaling requires precise levels at different parts of our body,
What is calcium signaling?
Researchers used light-sheet microscopy to form 3-D images of the process in primary cortical neurons from embryonic rats.
Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.
Calcium signaling and its interacting networks are involved in mediating numerous processes, including gene expression, excitation-contraction coupling, stimulus-secretion coupling, synaptic transmission, induction of synaptic plasticity, and embryonic development. Many structures, organelles, receptors, channels, calcium-binding proteins, pumps, transporters, enzymes, and transcription factors are involved in generating and decoding the different calcium signals in different cells.
Powerful methods for measuring calcium concentrations, advanced statistical methods, and biophysical simulations are used to model calcium signals. Calcium signaling is being studied in many cells and model organisms to understand the mechanisms of many physiological processes and the pathogenesis of many diseases, including cancers, diabetes, and neurodegenerative disorders.
Studies in calcium signaling are being used for understanding the mechanisms of actions of drugs and for the discovery of new drugs for the prevention and treatment of many diseases. Study of Ca2+ signaling is helpful in understanding the pathogenesis of many diseases including that of diabetes, and the neurodegenerative diseases, and in understanding the mechanisms of action of drugs used in the treatment of these diseases. Many calcium channel blockers are being extensively used in the treatment of hypertension and atrial fibrillation.
In biology, Ca2+ signaling is almost universal. Even bacteria use Ca2+ as a signal; they sense Ca2+ by using the so-called two-component regulatory systems consisting of a sensor kinase and a response element. To understand different biological phenomena and many human diseases, Ca2+ signaling is being studied in many model organisms, including Drosophila melanogaster, Saccharomyces cerevisiae, Caenorhabditis elegans, and zebrafish, and such research have led to important discoveries. The study of Ca2+ imaging in the zebrafish has helped our understanding of the development processes, many other physiological processes, and the roles of disease-related genes in a vertebrate system.
"I received AIC therapy since I was diagnosed with severe osteoporosis with T-score of -3.7. After about 9 months, my bone density is back to the normal range. Incredible!!"
M. S. PARK – Age 55, Male
Fracture Healing Effects of AIC Therapy
Steroid Induced Osteoporosis, auto fracture (Male, 52, Indonesia)
Dosage: MaraGen 2x /day for first 2 months and then only 1x. Able to walk normally again
Decalcification Effects of AIC Therapy
Removing Calcification from Cellular to Systemic Level is a Key to Recovery
DENTAL APPLICATION of AIC Therapy
Without bone grafts, AIC can fill cavitation after just cleaning it.
“Six months ago, I underwent an extraction, and my dentist recommended an implant after a bone graft. However, I expressed concern about my low jaw bone density and decided to delay the procedure. Despite my dentist’s insistence that there was no way to increase jaw bone density, I started AIC therapy. After a few months, I revisited my dentist and was thrilled to see the positive results of the X-rays. The increased jaw bone density made the implant procedure possible, much to my dentist’s surprise. It’s amazing what progress can be made with the right treatment!”
AIC therapy IN BONE LYTIC LESION
AIC is used to treat bone metastasis in integrative oncology (Carcinoma of Right Breast, Stage 4, age 80, female)
AIC application in Dermatitis (Eczema)
This 41 year old Canadian had her long term dermatitis resolved in 10 months of AIC therapy
AIC Application in Atopic Dermatitis
After suffering eczema since childhood, she found complete solution through AIC therapy within one year. First 3-6 months of the treatment had healing reactions.
AIC Application in Psoriasis case
•Diagnosed with the condition in August 2017.
•Symptoms improved with 6 months of AIC Treatment.
•Healing reaction experienced for the first week of the treatment but started getting better afterwards.
•Switched over to maintenance dosage after symptoms improved significantly.
•Scars took more than a year to disappear.
“In the case of T and B lymphocytes, these signals give rise to multiple changes in intracellular DNA expression, with the consequent production of various inflammatory markers. Research in this area also has established the importance of Ca2+ pathways in the development of autoimmune diseases, both due to overproduction as well as inactivity.” - From a Research
CONFERENCE PRESENTATIONS BY COLLABORATING PHYSICIANS
AIC ionic calcium therapy is currently used by hundreds of participating physicians around the world successfully.
19 years of gout is no more with AIC Therapy
“Nothing helped,” says a patient from Singapore who suffered 19 years of gout pain. He tried everything to ease his gout pain unsuccessfully. Even though he felt skeptical about spending more money on a new therapy, he felt much better in a matter of days and soon afterward could do anything on his feet again after taking AIC,
7 YEARS OF CANCER STRUGGLE COMES TO AN END WITH AIC
Diagnosed with cervical cancer in 2012, Joanna underwent surgery, chemo, and radiation, but the cancer returned. She traveled around the world for alternative treatments, such as cryo-ablation and ethanol-ablation did not help her much either. After trying AIC therapy, she was finally declared clinically cancer free in 2020 and remains still cancer-free in 2023.
AIC therapy Applications
Here are some reference books to delve deeper into understanding calcium signaling and the science and application of ionic calcium therapy. They are shared here for your reference only and ACRI does not make any medical claims on the content of these books.
Expectations For AIC Therapy
Above is sample AIC dosing for oncology protocol where 4 daily doses are recommended. All other applicable conditions are recommended at 3 daily doses.
AIC Therapy can be used in conjunction with other treatments as it promotes the calcitonin-based natural bone-remodeling process and consequently restores calcium balance at the cellular level. However, it may take time for the systemic effects of these cellular changes to manifest. Bone markers such as CTx and P1NP or bone scans such as REMS and DEXA can detect these changes. We suggest that patients take AIC Therapy for a minimum of 3 doses a day for at least 3 months to experience its positive effects. We recommend patients continue for another 3 months to experience more positive benefits (total 6 months).
It's worth noting that the role of ionic calcium is vital in multiple physiological processes. However, since it cannot be targeted to work on specific areas, patients may notice improvements in other areas before achieving their desired results.
Book an online session
If you are a physician and want to know more about AIC Therapy, Please book a free 25-minute 1:1 session.
AIC Therapy health benefits
Cellular Recovery Helps to Restore Mitochondrial Function, Reduce Oxidative Stress, and Correct Cell Signaling, which has
positive benefits for conditions listed here and more.
Autoimmune disease (Lupus, Vitiligo, Hashimoto’s, Crohn’s, Celiac disease, eczema, MS, rheumatoid, etc.)
Lyme disease, HIV, Shingles and other viral infections
Parkinson’s, ALS, Alzheimer’s and other neurodegenerative diseases
Arthritis, Gout, CPPD, Inflammations
Mitochondrial Disease
Cancer (carcinoma, sarcoma, lymphoma, leukemia, multiple myeloma)
Arrhythmia, Heart palpitation, Mitral Valve Prolapse,
Diabetes, Metabolic Syndrome
Thrombosis, Hemolytic Anemia
Autism Spectrum Disorder,
ADHD, Epilepsy
Asthma, COPD
Glaucoma, Cataract, Intermittent Exotropia, Retinal Vein Occlusion
Dysmenorrhea, infertility
Menier’s Disease, Aurora Migraine Disease, Tinnitus, Vertigo
Osteoporosis, Bone Necrosis
Chromosome 8 syndrome
Chronic Kidney Disease
Gum disease, Loose teeth
Calcification (joints and tissues), Calcific tendonitis, Fibrosis, Kidney and Gall Bladder Stones
Leave us a comment
