Cancer cells thrive in an acidic microenvironment due to increased glycolysis and lactic acid production, known as the Warburg effect. This acidic environment promotes cancer cell invasion and metastasis. Anti-Orbital Ionic Calcium (AIC) therapy alters the microenvironment of cancer cells to be more alkaline, making the cancer cells more visible to the immune system.

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Regulated increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion, cytotoxicity, apoptosis, and numerous gene transcriptions. AIC therapy restores calcium signaling, which is of paramount importance to proper immune function.

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